Compared with traditional non-covalent inhibitors, covalent inhibitors can achieve higher binding affinity and longer residence time. These characteristics can be realized into lower doses, dosing frequency and systemic exposure of drugs. Therefore, many pharmaceutical companies have initiated drug development programs for covalent inhibitors of various enzymes. Chemistry Calculation https://www.computabio.com/calculation-service-of-transition-metal-catalytic-reaction-mechanism.html
